中国组织工程研究

中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (10): 1617-1625.doi: 10.3969/j.issn.2095-4344.1610

• 生物材料综述 biomaterial review • 上一篇    下一篇

双膦酸盐药物复合支架在骨缺损局部的应用

崔宇韬，李容杭，刘 贺，王中汉，李升扬，冀 璇，杨 帆，关文启，李祖浩，吴丹凯   

  1. 吉林大学第二医院骨科，吉林省长春市 130041
  • 收稿日期:2018-11-21 出版日期:2019-04-08 发布日期:2021-04-28
  • 通讯作者: 吴丹凯，主任医师，教授，硕士生导师，吉林大学第二医院骨科，吉林省长春市 130041
  • 作者简介:崔宇韬，男，1995 年生，汉族，吉林大学第二医院骨科在读硕士，主要从事骨组织生物工程支架的研究。
  • 基金资助:

    国家自然科学基金(81671804，81772456，81171681)，项目参与者：刘贺

Application of bisphosphonates incorporated into scaffolds in bone defects

Cui Yutao, Li Ronghang, Liu He, Wang Zhonghan, Li Shengyang, Ji Xuan, Yang Fan, Guan Wenqi, Li Zuhao, Wu Dankai   

  1. Department of Orthopedics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • Received:2018-11-21 Online:2019-04-08 Published:2021-04-28
  • Contact: Wu Dankai, Chief physician, Professor, Master’s supervisor, Department of Orthopedics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • About author:Cui Yutao, Master candidate, Department of Orthopedics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • Supported by:

     the National Natural Science Foundation of China, No. 81671804, 81772456 and 81171681 (all to LH)

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摘要：

文章快速阅读：

 

 

文题释义：
骨组织工程：是一种结合材料工程与生物学知识和技术来使受损骨组织再生的技术，它包括了基于基因、细胞和细胞活性药物的治疗，主要包括种子细胞、支架材料和生长因子3个重要因素。
双膦酸盐药物：是有效的破骨细胞抑制剂，可抑制破骨性骨的重吸收，促进成骨细胞的增殖分化，是目前治疗骨质疏松症的一线药物，将其负载于骨组织工程支架可在骨缺损局部形成药物缓释，促进骨缺损局部新骨的形成，加速缺损的修复。
 
 
背景：在骨缺损愈合过程中，将负载药物的生物材料植入缺损局部进行干预，可加速缺损的修复，这为骨缺损局部治疗提供了新的方法。
目的：介绍负载双膦酸盐药物骨组织工程支架在骨缺损局部的应用，总结其对缺损愈合过程的影响。
方法：作者以“bisphosphonates，alendronate，zoledronate，bone defect，bone tissue engineering；双膦酸盐，阿伦膦酸盐，唑来膦酸盐，骨缺损，骨组织工程”为关键词，检索2006至2018年期间PubMed、Web of Science、Springerlink、Medline、万方、CNKI数据库中发表的相关文献。初检文章235篇，筛选后对70篇文章进行分析。

结果与结论：双膦酸盐药物是一种有效的破骨溶解抑制剂，其也可促进成骨细胞的增殖分化。将双膦酸盐药物负载于复合支架，可在缺损局部形成药物缓释系统，促进新骨形成，加速缺损的愈合。在双膦酸盐药物缓释系统方面，合适的支架材料对复合支架在缺损局部发挥成骨效应至关重要。目前应用于双膦酸盐药物复合支架的载体材料主要分为有机材料和无机材料2大类，其中大多数聚合有机材料可直接负载双膦酸盐药物，在局部形成良好的药物缓释，并可发挥明显的促进成骨效应；天然材料及大多无机材料则常与其他材料形成复合材料作为载体，从而优化载体的性能，大多数研究也证实了这些复合材料负载双膦酸盐药物在缺损局部的成骨作用。

ORCID: 0000-0003-2011-9319(崔宇韬)

 

关键词: 双膦酸盐, 骨缺损, 骨组织工程, 局部呈递, 药物治疗, 生物材料

Abstract:

BACKGROUND: In the process of bone defect healing, the use of biological materials loaded with drugs for local defect intervention can accelerate the repair of the defect, which provides a new method for the local treatment of bone defects.

OBJECTIVE: To introduce the local application of bone tissue engineering scaffolds loaded with bisphosphonates in bone defect repair and to summarize the effects of bone tissue engineering scaffolds as a drug delivery system on the bone defect healing.
METHODS: The authors retrieved PubMed, Web of Science, Springerlink, Medline, WanFang and CNKI databases with “bisphosphonates, alendronate, zoledronate, bone defect, bone tissue engineering” as key words for relevant articles published from 2006 to 2018. Initially, 235 articles were retrieved, and finally 70 articles were selected for further analysis.

RESULTS AND CONCLUSION: Bisphosphonate drug is an effective inhibitor of osteoclast dissolution. It can form a drug sustained release system on the local defect by being loaded to composite scaffolds, promote the formation of new bone and accelerate the healing of the defect. For the drug delivery system of bisphosphonates, suitable scaffold materials are crucial to the osteogenic effect of composite scaffolds in the defect area. At present, the carrier materials used for bisphosphonate-loaded composite scaffolds are mainly divided into organic materials and inorganic materials. Most polymeric organic materials can directly load bisphosphonates to form good drug sustained release in the local area and obviously exert their pro-osteogenic effects, while natural materials and most inorganic materials are often combined with other materials to form composite materials as carriers to optimize the carrier performance. Most studies have also confirmed that these composite materials loaded with bisphosphonates in the defect area exert osteogenic effect in the defect area.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Diphosphonates, Tissue Engineering, Bone Transplantation

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